IMPE Abstracts

Background: Physical condition is related with degree of physical activity performed. Daily physical activity is part of non-pharmacological treatment for adolescents with type 1 diabetes (T1D) due its effects in glycaemia stability and reducing cardiovascular risk. However, several studies have observed poor physical condition in adolescent with chronic diseases.Objective: To evaluate physical condition in adolescents w...

The purpose of the study was consisted in evaluating the general clinical laboratory characteristics of children using insulin degludec. Material and methods: 42 children with type 1 diabetes mellitus were monitored. Blood glucose and glycohemoglobin were determined by laboratory methods. Statistical calculations were analyzed using Statistica 14.0 statistical software. Results and their discussion: the average age of the examined children was 11.4±4.07 years, the duration ...

A 37 wk of gestation newborn male from a mother with Gestational diabetes also IUGR, consanguineous parents, with persistent glucose levels around 425 mg/dl since his second postnatal day of life with Birth weight of 1640 grams (SD -4.4) and Birth length 41 centimeters (SD -4.6). A diagnosis of Neonatal Diabetes was made and initially he was treated with intravenous insulin to later be switched to SC insulin, basal-prandial therapy analogues (Lispro 0.5 IU if glucose >250 m...

Introduction: 6q24-related transient neonatal diabetes mellitus (6q24-TNDM) is defined as transient neonatal diabetes mellitus caused by genetic aberrations of the imprinted locus at 6q24. The cardinal features are: severe intrauterine growth retardation, hyperglycemia that begins in the neonatal period in a term infant and resolves by age 18 months, dehydration, and absence of ketoacidosis.Objectives: In this presentati...

Mauriac syndrome (MS) is a rare complication of type 1 diabetes mellitus (DM1). It is related to low insulin concentrations and is less common since longer-acting insulins became available. It is characterized by hepatomegaly, edema, growth and puberty delay, and the presence of elevated transaminases and serum lipids. Its incidence is decreasing due to the new types of insulin and intensive glycemic control. Therefore is a rare diagnosis in Europe nowadays, being described ma...

Introduction: Monogenic diabetes is uncommon cause of diabetes mellitus (DM) due to single gene mutation and accounts for 1-6% of paediatric diabetes. It includes neonatal DM (NDM), maturity onset diabetes of the young (MODY) and rare diabetes-associated syndromes. They are frequently misclassified as either type 1 or young-onset type 2 diabetes. The genetic confirmation has a substantial impact on clinical management, prognosis and genetic counselling.<p ...

Neonatal Diabetes (ND) is a rare genetic disease (1 in 90,000 live births); most cases will be diagnosed before 6 months of age. The third cause by frequency, is mutations of the insulin gene (INS); the majority are heterozygous mutations a&fflig;ecting the structure of preproinsulin; these are transmitted in an autosomal dominant manner.Clinical case: Third Child of non-consanguineous parents, male, controlled pregnancy at high obstetri...

Introduction: MODY is a heterogeneous group of monogenic disorders that occurs due to β cell dysfunction. The estimated MODY prevalence is around 1–5% of all diabetes mellitus cases, but it varies depending on the population studied. MODY2 is caused by heterozygous inactivating mutations in the glucokinase (GCK) gene loci 7p13. That result in persistent, stable and mild fasting hyperglycemia, glycosylated hemoglobin alterations. Patients with GCK mu...