IMPE Abstracts

Objectives/Background: Type 1 Diabetes (T1D) manifests as a loss of insulin secretion due to autoimmune destruction of β-cells by self-reactive T effector lymphocytes. Suppression of autoreactive T effectors by regulatory T cells (Tregs) is a key mechanism of peripheral self-tolerance. T1D subjects have documented numerical and functional Tregs impairment. Recent early-stage clinical trials with adoptively transferred ex vivo-expanded autologous Tregs sho...

Perceived diabetes stigma (PDS) has been associated with worse clinical and psychosocial outcomes in adults. Our objective was to examine the associations between PDS, glycemic control, diabetes complications, psychosocial variables, and substance use in adolescents and young adults (AYAs) with type 1 diabetes (T1D) and type 2 diabetes (T2D) in the SEARCH for Diabetes in Youth study, 2016-2019. We hypothesized that greater PDS was associated with worse glycemic control, greate...

Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk and impaired skeletal muscle function. Myostatin (GDF8), a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bone formation. We investigated whether an inhibitory myostatin antibody in streptozotocin (STZ)-induced diabetes mouse model is protective for bone and skeletal muscle. DBA/2J male mice (n=9 -10/group) were injected with low-d...

Background: Emerging scientific evidence has revealed the connection between iron metabolism and type 2 diabetes mellitus. The liver is the major iron storage organ and is considered a marker of total body iron stores. Liver biopsy is invasive and biased, therefore iron measurement by magnetic resonance imaging (MRI) has emerged as a widely accepted method. Actually, there are no studies evaluating the presence of hepatic iron overload in patients with youth-o...