IMPE Abstracts

Background: Pediatric papillary thyroid cancer (PTC) is traditionally treated with total thyroidectomy and radioactive iodine (RAI). However, growing evidence suggests that not all patients benefit from RAI. Our objective was to describe clinicopathologic features and outcomes of patients with pediatric PTC who did not receive upfront adjuvant RAI therapy.Methods: Using an IRB-approved database at a tertiary referral can...

In the setting of iodine excess, organification of thyroglobulin is blocked, serving as a protective mechanism against hyperthyroidism. This phenomenon, the Wolff-Chaikoff effect, can result in persistent hypothyroidism. Excessive iodine exposure is usually iatrogenic, coming in the form of radiographic dyes, amiodarone, and povidone-iodine antiseptic solution. In March 2022, the US Food and Drug Administration (FDA) released a statement that at-risk children up to age 3 years...

Background: Thyroid function tests are the most performed endocrine test indicated in various disorders. Appropriate assessment is essential for the timely diagnosis and management of these disorders. Lack of access to specialist pediatric endocrine care makes interpretation of thyroid function tests in resource-poor settings. There is a need for developing a point-of-care tool for guidance on thyroid function interpretation.Aim:...

Introduction: Thyroid Hormone Resistance (THR) is an uncommon genetic condition caused by decreased tissue sensitivity to thyroid hormones (THs). The main finding is the presence of elevated THs levels with unsuppressed TSH. In THR clinical signs of hormonal deficiency, sufficiency and excess can coexist.Aim: To report the clinical and biochemical findings in patients withTHR, highlighting common characteristics that cou...