IMPE Abstracts

Objectives: KCNK16 gene encodes the two-pore-domain K+ channel, TALK-1, which is expressed on both the β-cell plasma membrane and the ER membrane. The KCNK16-containing locus is strongly associated with type 2 diabetes mellitus in multiple genome-wide association studies in the general population. Its mutation inducing a gain of function in TALK-1 has been recently reported to cause MODY. No case of KCNK16-MODY has been reported to date besides the family...

Up to 45% of youth with type 1 diabetes (T1D) have cardiovascular (CV) risk factors and may develop subclinical cardiovascular disease in the first decade of diagnosis. Physical fitness in youth have been shown to be associated with cardiometabolic risks factors among youths with and without diabetes.Aim: To examine the association between handgrip strength and cardiorespiratory fitness and the compliance of the ADA/ISPAD clinical guidel...

Background: Type 1 diabetes mellitus (T1DM) and autoimmune diseases, such as autoimmune thyroiditis (AT) or coeliac disease (CD) frequently occur together. Adiponectin is the most abundant circulating adipokine that plays a key role as an insulin-sensitizing protein in metabolic diseases. Autoimmune diseases are associated with decreased levels of adiponectin, previous studies suggesting that adiponectin may be related to disease activity and/or severity in su...

Introduction: The optimal control of type 1 diabetes mellitus (DM1) has been a challenge over time, especially in the pediatric population. A high proportion of patients do not achieve glycemic targets, which has led to the search for new strategies to optimize metabolic control. Recently, advanced hybrid closed-loop system (AHCL) have been designed to combine automated basal insulin delivery with automated five-minute correction boluses integrated to continuo...

Objective: Type 1 diabetes mellitus (T1D) incidence in children varies across regions and countries. A large incidence increase has been observed in several countries during the COVID-19 pandemic. The objective of this study is to determine the trends in T1D incidence rates in Chilean children between 2006 and 2021, and specifically evaluate the effect of COVID-19 pandemic in this population.Methods: We reviewed mandator...

Objective: To describe the appendicular skeleton strength (ASS) and the associate factors in adolescent with diabetes mellitusMethodology: Cross-sectional study in puberal patients (9 to 18 years) with DM. By means of clinical records review, we corroborated demographic, auxology and biochemical variables as well as the presence or not of complications. Body Satisfaction Discomfort (BSD) was evaluated using Stunkard silh...

Introduction: Dental caries carries a high global prevalence particularly in children and adolescents with diabetes. Salivary flow rate and glucose levels have been implicated in the higher prevalence. However, some studies show controversial results of lower dental caries in children with diabetes compared to healthy children. There is lack of data on this topic in the Arab region where both diabetes and dental caries are common. We aim to compare the prevale...

Introduction: SOFT syndrome (MIM#614813), denoting Short stature, Onychodysplasia, Facial dysmorphism, and hypoTrichosis, is a rare primordial dwarfism syndrome encompassing severe growth failure of prenatal onset, craniofacial dysmorphism, sparse hair, and digital abnormalities associated with biallelic pathogenic POC1Agene variants. Phenotypic spectrum has recently been expanded to include insulin resistance (IR) and muscle cramps.<p class="abst...

Background: The incidence of type 1 diabetes has increased worldwide whereas a long-term trend for pediatric type 1 diabetes has remained elusive in Japan. Because a nationwide registry system for pediatric type 1 diabetes has not been established in Japan, it is difficult to simply extrapolate a national epidemiological study from the MAPChD data in Japan. The local registry systems in each prefecture or small-scale adjacent areas would be better for extracti...

Introduction: One of the pillars of type 1 diabetes mellitus (T1DM) treatment is nutritional management with carbohydrate counting (CC), which requires constant control of food consumed, learning mathematical reasoning, or using mobile apps to calculate the amount of insulin administered before meals. CC can be hampered by Attention Deficit Disorder and Hyperactivity Disorder (ADHD), characterized in childhood by hyperactivity, impulsivity, and inattention.</p...

Type 1 Diabetes Mellitus (T1D) is a chronic illness that impacts the quality of life (QoL) of patients and their families. Currently, different methods exist that facilitate glycemic control and insulin administration to achieve good metabolic control, which may contribute to a better QoL. Perú is a middle-income country with low prevalence of T1D and low access to diabetes technology. We evaluated the QoL in children and adolescents with T1D using different methods of ...

Monogenic diabetes is a group of diabetes subtypes that can be classified as neonatal diabetes and maturity onset diabetes of the young. Here we present 12 confirmed patients for monogenic diabetes at the Hospital Universitario del Valle at Cali, Colombia from 2014 to the present year from our total population of 412 patients with CIE10 diagnosis of diabetes in patients under the age of 18 years of age. Here we documented mutations associated with MODY on the GCK gene for 3 pa...

Background: Guidelines for safe fasting strategies exist for both adolescents and adult patients living with type 1 diabetes (T1DM). Management of T1DM during fasting is complex, however, strategic approaches including insulin adjustments, education, and nutritional modifications to reduce the likelihood of hypoglycemia.Aim: This prospective study assessed the safety and effectiveness of an advanced hybrid closed-loop (A...

Introduction: Insulin sensitivity is a marker of cardiovascular health. Young women in reproductive age with type 1 diabetes (T1D) have an increased risk of cardiovascular disease. The metabolic effects of combined oral hormonal contraception (OC) and progestin implant (implant) on insulin sensitivity in young women with T1D are unknown.Objective: To determine the effect on insulin sensitivity in young women with T1D of ...

Introduction: Neurogenin-3 (NEUROG3) is a key transcription factor expressed in endocrine progenitor cells and is necessary for the development of endocrine cells in the pancreas and intestine. Its homozygous pathogenic variants cause an autosomal recessive disorder characterized by congenital malabsorptive diarrhea due to paucity of enteroendocrine cells and diabetes which occurs from the neonatal stage to school age.Objectives:...

Objective: To understand how integration of an interactive eBook resource impacts inpatient diabetes education at an academic medical center.Purpose: Up to 20% of diabetes-related errors in pediatric inpatient settings occur among medical trainees, largely because current educational strategies are variable and limited. In response, we created a novel interactive eBook resource about inpatient diabetes management using K...