IMPE Abstracts

Background: Obesity onset at early ages influences skeletal maturation, growth and the onset of adrenarche and puberty. How this influence is exerted, the differences between sexes and the influence of obesity severity are insufficiently addressed.Objectives: To explore the patterns and pace of pubertal development, including the pre- and pubertal growth spurt in children and adolescents affected with obesity.<p clas...

Background: The central melanocortin system is involved in metabolic control, receiving, and integrating metabolic signals, such as leptin. Biallelic mutations in several genes of this pathway have been reported in severe obesity. However, whether and how heterozygous rare sequence variants (hetRSVs) in genes of the melanocortin system contribute to the development of obesity is poorly explored.Objectives: To explore the...

Background: Inborn errors of metabolism (IEM) are a consequence of genetic defects that lead to a metabolic block in a biochemical pathway critical to tissue-specific cellular functions. Prompt and effective intervention in screening-positive patients is particularly important in cases of IEM. Newborn mass screening has developed aiming to identify newborns who appear healthy but who could be at risk of developing metabolic attacks with the potential to lead t...

Objective: To investigate the characteristics of gut microbiota in children with disparate degrees of adiposity, and analyze the association between gut microbiota, glucose metabolism indicators and inflammatory factors.Methods: Clinical data were examined in 89 Chinese children. Children with body fat (BF)% ≥ 30% were diagnosed as obesity, and ≥ 35% in males and ≥40% in females were further defined as severe ob...

Objectives: To investigate the associations of obesity with growth and puberty in children.Methods: From November 2017 to December 2019, height, weight, and Tanner stages of 26879 children aged 3-18 years in Fuzhou, China were assessed.Results: The obesity group was significantly taller than the non-obesity group after 4 years-old for both genders, yet there was no significant diff...

Background: Healthy living, as well as treatment of overweight and obesity, includes a trend towards personalized diets. To better design these diets, predicting an individual’s metabolic response to specific nutrients is necessary and to do so we must understand how nutrients are perceived by metabolic circuits and to identify the signals involved. Moreover, as males and females respond differently to an obesogenic environment, how energy perception dif...

Background: The assessment of childhood obesity involves the rational use of diagnostic tests in physiological causes while not missing pathologies. We have developed an obesity interpreter, a mobile application that provides individualized guidance regarding the workup of children and adolescents.Aim: To develop and validate a mobile application to evaluate children and adolescents with obesity.<s...

Objective: to assess the association of different markers of adiposity during childhood with different pubertal milestones (age at: thelarche, pubarche, menarche, and peak height velocity (PHV)).Design: longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort Study.Setting: A population-based study from the low-middle socioeconomic status of the So...

Introduction: The melanocortin-4 receptor (MC4R) pathway is an important regulator of energy balance and body weight. Several key genes are associated with the MC4R pathway, including POMC, PCSK1, LEPR, NCOA1, and SH2B1. These genes work in concert within the hypothalamus to regulate leptin signaling and activation of MC4R. However, the molecular mechanisms of these genes and the clinical characteristics of individu...

Background: Sarcopenia is a common disorder among elderly people defined by the loss of skeletal muscle mass accompanied by a physical function disorder. In recent years, it has been reported that the loss of skeletal muscle mass is a poor prognostic factor in pediatric cancer patients as well as adult cancer patients. In the elderly, a decrease in IGF-1 was suggested to be one of the responsible factors in the development of sarcopenia, but there have been no...

Bariatric surgery is becoming a modality of treatment for severe obesity in adolescents. Referral to surgery is governed by certain policies which mandates presence of certain comorbidities. Family history of bariatric surgery might encourage families to seek surgery referral for adolescents with severe obesity as anti-obesity medications are not widely available and lifestyle modifications are challenging. The study design is observational retrospective inclusive of patients ...

Background: Domestic and international epidemiological studies have reported that childhood obesity and serum lipids were associated with lifestyle-related diseases in adulthood. There are few long-term epidemiological studies on the relationship between serum lipids and obese in Japanese children.Purpose: Based on the data Oita City schoolchildren lifestyle-related disease screening program (height, weight, serum total ...

Objectives: Vitamin D deficiency is prevalent in pediatric population. Since low compliance may inhibit appropriate vitamin D supplementation in daily dosing regimen, intermittent high dose administration may be considered. We aimed to evaluate the efficacy and safety of monthly administration of oral cholecalciferol compared with daily dosing regimen in adolescents with vitamin D deficiency.Methods: This retrospective s...

Background: Most children and adolescents with obesity have metabolic complications; however, a substantial proportion of these remain metabolically healthy. A paucity of data about the course of children and adolescents with metabolically healthy obesity is unclear due to limited information.Aim: To determine the course and its predictors of metabolically healthy obesity in obese Indian children and adolescents.<p c...

Monogenic obesity is a rare, severe condition, associated with early-onset weight gain. In the last years, due to advances in genetic technique and sequencing technology, an increasing number of variants causing monogenic obesity has been described, mostly genes encoding components of leptin-melanocortin pathways. The accessory protein MRAP2 (Melanocortin Receptor Accessory Protein 2) acts in body weight regulation and its inactivation is associated with early-onset severe obe...