Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)

IMPE Abstracts

Published by BioScientifica
Volume 96 | IMPE2023

IMPE 2023

Buenos Aires, Argentina
04 Mar 2023 - 07 Mar 2023

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11th International Meeting of Pediatric Endocrinology (IMPE 2023). 4 -7 March 2023 - Buenos Aires, Argentina.

Poster Presentations

Pituitary, Neuroendocrinology and Puberty

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Multisystem Endocrine Disorders
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Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology

impe0096p112 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Rapid Weight Gain in Early Life is Associated with Central Precocious Puberty; a Nationwide Population-based Study

Ho Cha Jong , Jin Kim Yun , Yoon Na Jae , Choi Jinjoo , Choe Yunsoo , Yang Seung

Objectives: This study aimed to investigate the effect of rapid weight gain in infancy and toddler period on the incidence of central precocious puberty (CPP) using nationwide population-based data.Methods: A total of 921,191 children (454,392 girls) who had regular health check-up by National Health Insurance Service (NHIS) during 2007-2017 were followed up until the age of 9 years old for girls (10 years old for boys) ...
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impe0096p113 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Predicted structural destabilisation of GnRHR Arg139His pathogenic variant in a boy with hypogonadotrophic hypogonadism.

Urrutia Mariela , Brunello Franco , Sansó Gabriela , Castro Sebastián , Scaglia Paula , Izquierdo Agustín , Esnaola Azcoiti Maria , Gabriela Ropelato María , Grinspon Romina , Rey Rodolfo

The genetic defects underlying hypogonadotrophic hypogonadism (HH) are known in approximately 50% of cases. In normosmic patients, abnormal GnRH production or action may be due to defects in regulatory factors or in the genes encoding GnRH or GnRHR. Although many gene variants have been described in GNRHR (4q13.2), the potential impact of structural alterations of the resulting mutant proteins have not been studied. In this study, we analysed the 3D-structure of the variant Gn...
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impe0096p114 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Rare plurihormonal Pit-1 adenoma presents as severe isolated clinical hyperthyroidism in 15 year old adolescent

Palting Rachel , Baines Hayley , Collins Kelly

Objective: 15 year old adolescent presented with clinical hyperthyroidism consisting of 6 month weight loss, diarrhea, disrupted sleep, heat intolerance and tremor with objective tachycardia and hypertension. Initial labs demonstrated concomitantly elevated free T4, total T3 and TSH. No concerns for excess growth hormone nor galactorrhea. He was appropriate height for genetic potential and Tanner IV pubertal development. Patient’s presentation led to rar...
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impe0096p115 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Trends in Idiopathic Central Precocious Puberty (ICPP) incidence during the last decade and Covid19-pandemic lockdown impact. A case-control study.

Benedetto María , Riveros Valentina , Eymann Alfredo , Pasqualini Titania , Terrasa Sergio , Alonso Guillermo

Introduction: Stress levels and/or changes in lifestyle resulting from covid-19 lockdown imposed on the pediatric population, could be determinant factors in the incidence of ICPP. Objective: To describe changes in the incidence of ICPP in a selected population and to compare these cases with lockdown exposed controls.Materials and methods: ICPP girls who started GnRH analogue (GnRHa) treatment after lockdown, belonging ...
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impe0096p116 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Evaluation of Brain Nuclear Magnetic Resonance Findings in Patients with Apparently Idiopathic Central Precocious Puberty (Cpp) Aged Between 6 and 8 Years at Diagnosis

Arcari Andrea , Freire Analía , Díaz Marsiglia Yenifer , Morín Analía , Ricci Jaime , Gabriela Bastida María , Alonso Guillermo , Gryngarten Mirta

Introduction: CPP is the onset of secondary sexual characteristics before the age of 8 years for girls, due to early activation of the hypothalamic-pituitary-gonadal axis. Near 90% of girls have idiopathic CPP, in rare cases, CPP may occur due to intracranial pathology causing organic CPP. Brain Magnetic Resonance Imaging (B-MRI) with gadolinium is the tool to exclude organic CPP. There is controversy regarding the need for MRI testing in CPP girls whose puber...
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impe0096p117 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

CBL-Related Disorder in A Boy with Microcephaly and Growth Hormone Deficiency

Janchevska Aleksandra , Tasic Velibor , Jovanovska Valentina , Jordanova Olivera , Gucev Zoran , Plashevska Dijana

Introduction: Noonan syndrome-like is a developmental disorder with heterogenic phenotype (macrocephaly, dysmorphic facial features, congenital heart disease, motor delay, short stature in 31% of cases etc.). These patients carry rare heterozygous mutations in the CBL gene, with an increased risk of malignancies, particularly juvenile myelomonocytic leukemia.Methods: A 2.5-year-old boy, born in term with intrauterine gro...
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impe0096p118 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Clinical, anthropometric data and laboratory results of girls with precocious puberty before and during COVID-19 pandemic lockdown.

Fittipaldi Yamila , Florencia Kuspiel Maria , Troiano Marina , Alvarez Karina , Di Giusseppe Luis , Pasqualini Titania , Alonso Guillermo

Introduction: Several studies suggested that there was an increased incidence of precocious puberty in girls during the lockdown for COVID-19 pandemic.Objective: To compare clinical and biochemical parameters in ICPP girls treated before and after lockdown.Patients and methods: Electronic registry data from girls treated with GnRH analogue (GnRHa) attending at a single Hospital, be...
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impe0096p119 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

IMPACT of The COVID-19 Pandemic on The Incidence of Central Precocious Puberty: A Systematic Review

Cheuiche Amanda , Moro Candice , Silveiro Sandra , Czepielewski Mauro , de Paula Leila

Introduction: Puberty is a biological maturation process that involves genetic, metabolic, environmental, ethnic, geographic, and economic factors. During the coronavirus 2019 (COVID-19) pandemic, an increase in referrals for central precocious puberty (CPP) assessment was observed in clinical practice.Methods: We evaluated the incidence of CPP before and during the COVID-19 pandemic in different countries. A PRISMA-comp...
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impe0096p120 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Abstract Withdrawn...
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impe0096p121 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Long term use of tolvaptan in a child with chronic SIADH secondary to intracranial teratoma

Miyagi Hajime , Noordin Mazidah , Igarashi Mizuho , Horikawa Reiko

Tolvaptan, a V2-receptor antagonist, is used for the treatment of chronic hyponatremia in adult patients with syndrome of inappropriate antidiuretic hormone secretion (SIADH). However, its use in children has not been established. Here we present a child case of chronic SIADH successfully treated with tolvaptan. The patient is a 5-year-old boy with congenital intracranial teratoma, complicated with hydrocephalus and severe motor and mental retardation. He has combined central ...
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impe0096p122 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Did the prevalence of Central Precocious Puberty increase in girls during the Covid19 Pandemic? Comparison of cases diagnosed in a pediatric endocrinology service in Ciudad Autónoma de Buenos Aires in two periods: pre-pandemic and pandemic.

Jose Colombres Maria , Clara Casiello Ana , Rapelius Stefania , Della Pia Belen , de las Mercedes Argibay Molina Maria , Stedile Graciela , Brunetto Oscar , Figueroa Veronica

Introduction: Puberty is a complex biological phenomenon where secondary sexual characteristics develop, complete sexual maturation and adult size is reached. Central precocious puberty (CPP) in girls is defined as the progressive appearance of sexual characteristics before 8 years old, with advanced bone age and acceleration of growth velocity, due to pituitary gonadal axis activation. Multiple studies have shown an increased incidence of CPP and a faster rat...
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impe0096p123 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Effect of weight change on the diagnosis of central precocious puberty

Jeong Hwal-Rim , Heo Seung , Byul Kwon Eun , Suk Shim Young , Sang Lee Hae , Soon Hwang Jin

Objective: In girls, breast development under 8 years of age and peak serum luteinizing hormone (LH) is 5 IU/L or higher in gonadotropin releasing hormone (GnRH) stimulation tests is a standard method for diagnosing CPP. Because of higher body mass index (BMI) was associated with a lower LH response in the GnRH stimulation test, BMI should be considered when interpreting the result of GnRH stimulation tests. We aimed to find out whether changes in BMI affect t...
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impe0096p124 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Clinical features, response to treatment and long-term follow-up of prolactinomas in children and adolescents: A retrospective single centre analysis

Dabadghao Preeti , Nayak Sapna , Sajjan Shruti , Bhatia Vijayalakshmi

Background: Prolactinomas, the commonest pituitary adenomas are rare in children and adolescents. We aimed to study the clinical presentation, treatment response and long-term follow-up of young patients with prolactinomas.Methods: Single-centre retrospective cohort study of young (age <20 years) prolactinoma patients treated between July 2006 and July 2022. Relevant data was collected from hospital records and analys...
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impe0096p125 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

A multicentric study of germinoma with isolated pituitary stalk involvement during the pandemic of COVID-19 in Chile

Zepeda Diego , Guarda Francisco , Okuma Cecilia , Pablo Fernandez Jose , Naudy Cristián , Isabel Hernandez María

Introduction: Intracranial germ cell tumors (iGCTs) are rare neoplasms that mainly affect adolescents and young adults. iGCTs are divided into germinoma and non-germinomatous germ cell tumors. The hypothalamic-pituitary region is the second primary site of iGCTs after the pineal region. The iGCTs with isolated pituitary stalk involvement are rare and difficult to diagnose. They should be suspected when there is a pituitary stalk thickening >6.5 mm or a coex...
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impe0096p126 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Development and Validation of a Mobile Application-based assessment of Pubertal Disorders

Banerjee Sayan , Raithatha Dhwani , Agrawal Manoj , Yadav Vibha , Bajpai Anurag

Background: Assessment of pubertal disorders is challenging for the pediatricians causing unnecessary evaluation on one hand while missing pathology on the other. The paucity of pediatric endocrine centers further adds to the problem in resource poor settings. We have developed puberty interpreter, a mobile application that provides instantaneous guidance regarding diagnosis and management of children and adolescents with concern for pubertal disorders based o...
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impe0096p127 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Continuous arginine-vasopressin infusion during liver transplantation in a child with central diabetes insipidus and Langerhans cell histiocytosis.

Contreras Andy , Pino Consuelo , Godoy Claudia , Grob Francisca

Introduction: Central diabetes insipidus (CDI) affects 2 to 15% of children with Langerhans cell histiocytosis due to destruction of the neurohypophysis. Management includes access to free water and desmopressin (dDAVP), a synthetic analog of AVP, which has a longer half-life than vasopressin. dDAVP can be administered orally, intranasally, or parenterally, depending on the clinical setting. Protocols describing continuous infusion of dDAVP have been reported ...
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impe0096p128 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Neuroendocrine Tumor as a cause of Ectopic Cushing Syndrome in pediatrics

Quarracino Malena , Gil Silvia , Ciaccio Marta , Barrenechea Marcelo , Rizzi Ana , Felizzia Guido , Fabián Nader Julio , Isabel Di Palma María

Cushing’s syndrome (CS) is a rare pediatric endocrine disorder. Most cases originate from pituitary lesions and less than 1% are caused by ectopic ACTH-secreting tumors. A previously healthy 9-year-old girl developed abrupt weight gain, Cushingoid phenotype, and behavior changes over 5 months. Subsequently, she developed fever, diarrhea, abdominal pain, abnormal gait, and myalgia. She was admitted to a local hospital with symptomatic hypokalemia requiring IV potassium co...
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impe0096p129 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Accuracy Subcutaneous Gonadotropin-Releasing Hormone Agonist (Triptorelin) Test compare with Intravenous Gonadorelin test for diagnosing central precocious puberty

Ahn Jungmin , Byul Kwon Eun , Rim Jeong Hwal

Purpose: Gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for diagnosing central precocious puberty (CPP). However, intravenous GnRH is not always readily available. The purpose of this paper is to compare the results of gonadorelin and triptorelein used in the GnRH stimulation test in the diagnosis of CPP among girls.Methods: A retrospective clinical study (Intravenous Gonadorelin CPP VS Subcu...
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impe0096p130 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Hypothalamic Hamartoma Series

Jara Mirta , Godoy Claudia , Martinez Alejandro , Rumie Karime , Lacourt Patricia , Pizarro Hugo

Introduction: Hypothalamic Hamartomas (HH) are non-neoplastic, congenital and non-progressive malformations appearing during fetal development. They are located between the infundibular stalk and the mammillary bodies at the hypothalamus. They are manifested by gelastic seizures, delayed psychomotor development or central precocious puberty (CPP), which is the most frequent presentation. The mechanism involved in the genesis of CPP is poorly understood, and th...
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impe0096p131 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Is Basal Luteinizing Hormone Level Accurate for Diagnosis of Central Precocious Puberty?

Ugarte Francisca , Gallardo Vivian , Lai Kuang , Saul Taly , Garfias Carolina , Eyzaguirre Francisca , Urquidi Cynthia , Tolosa Bernardita , Jesús Vial María

Introduction: Central precocious puberty (CPP), the development of secondary sex characteristics before ages 8 and 9 years in girls and boys, is caused by premature activation of the hypothalamus-pituitary-gonadal (HPG) axis. A gonadotropin-releasing hormone stimulation (GnRH test) is the gold standard diagnostic method to confirm activation of the HPG axis and peak LH levels higher than 5 IU/L are considered a pubertal response. However, the GnRH test is expe...
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impe0096p132 | Pituitary, Neuroendocrinology and Puberty | IMPE2023

Craniopharyngioma Associated to Ocular and Brain Congenital Abnormalities

Tangari Saredo Ana , Garrido Jeniffer , Godnjavec Jesica , Abregu María , Rivera Manuel , Grosz Alejandro , Del Rey Graciela

Septo&dash;optic dysplasia (SOD) or Morsier's syndrome is a congenital developmental anomaly of the brain that could present absent of septum pellucidum and corpus callosum, optic nerve hypoplasia and pituitary hypoplasia. Gene variants of the transcription factors HESX1 SOX3, SOX2, and OTX2 had been described in SOD. The two latter are also causatives genes of anophthalmia. Craniopharyngioma (CP) is a tumor with low histological grade, the association to unilateral anoph...
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