IMPE Abstracts

It is unacceptable that 100 years after the discovery and first use of insulin, access to this essential medicine is poor in many countries. The reality for people needing insulin to survive is most acute in low- and middle-income countries (LMICs), as will be shown in a short clip filmed in 2020 in Peru, Mali and Tanzania. Insulin must be available in facilities when needed. The price and affordability of human and analogue insulins is also crucial – both to governments...

Background: Allgrove syndrome (AS) (OMIM MIM*231550) is a rare autosomal recessive multi-system disorder caused by a defect in the nucleoporin ALADIN due to mutations in the corresponding AAAS gene. It is characterized by adrenal insufficiency, achalasia, alacrima, and neurologic impairments. Here, we are presenting a large cohort of this syndrome from one country, highlighting the phenotype-genotype correlation in our patients and reflecting our difficulties ...

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