IMPE Abstracts

Monogenic diabetes is a group of diabetes subtypes that can be classified as neonatal diabetes and maturity onset diabetes of the young. Here we present 12 confirmed patients for monogenic diabetes at the Hospital Universitario del Valle at Cali, Colombia from 2014 to the present year from our total population of 412 patients with CIE10 diagnosis of diabetes in patients under the age of 18 years of age. Here we documented mutations associated with MODY on the GCK gene for 3 pa...

Background: Guidelines for safe fasting strategies exist for both adolescents and adult patients living with type 1 diabetes (T1DM). Management of T1DM during fasting is complex, however, strategic approaches including insulin adjustments, education, and nutritional modifications to reduce the likelihood of hypoglycemia.Aim: This prospective study assessed the safety and effectiveness of an advanced hybrid closed-loop (A...

Introduction: Insulin sensitivity is a marker of cardiovascular health. Young women in reproductive age with type 1 diabetes (T1D) have an increased risk of cardiovascular disease. The metabolic effects of combined oral hormonal contraception (OC) and progestin implant (implant) on insulin sensitivity in young women with T1D are unknown.Objective: To determine the effect on insulin sensitivity in young women with T1D of ...

Introduction: Neurogenin-3 (NEUROG3) is a key transcription factor expressed in endocrine progenitor cells and is necessary for the development of endocrine cells in the pancreas and intestine. Its homozygous pathogenic variants cause an autosomal recessive disorder characterized by congenital malabsorptive diarrhea due to paucity of enteroendocrine cells and diabetes which occurs from the neonatal stage to school age.Objectives:...

Objective: To understand how integration of an interactive eBook resource impacts inpatient diabetes education at an academic medical center.Purpose: Up to 20% of diabetes-related errors in pediatric inpatient settings occur among medical trainees, largely because current educational strategies are variable and limited. In response, we created a novel interactive eBook resource about inpatient diabetes management using K...

Background: Obesity onset at early ages influences skeletal maturation, growth and the onset of adrenarche and puberty. How this influence is exerted, the differences between sexes and the influence of obesity severity are insufficiently addressed.Objectives: To explore the patterns and pace of pubertal development, including the pre- and pubertal growth spurt in children and adolescents affected with obesity.<p clas...

Background: The central melanocortin system is involved in metabolic control, receiving, and integrating metabolic signals, such as leptin. Biallelic mutations in several genes of this pathway have been reported in severe obesity. However, whether and how heterozygous rare sequence variants (hetRSVs) in genes of the melanocortin system contribute to the development of obesity is poorly explored.Objectives: To explore the...

Background: Inborn errors of metabolism (IEM) are a consequence of genetic defects that lead to a metabolic block in a biochemical pathway critical to tissue-specific cellular functions. Prompt and effective intervention in screening-positive patients is particularly important in cases of IEM. Newborn mass screening has developed aiming to identify newborns who appear healthy but who could be at risk of developing metabolic attacks with the potential to lead t...

Objective: To investigate the characteristics of gut microbiota in children with disparate degrees of adiposity, and analyze the association between gut microbiota, glucose metabolism indicators and inflammatory factors.Methods: Clinical data were examined in 89 Chinese children. Children with body fat (BF)% ≥ 30% were diagnosed as obesity, and ≥ 35% in males and ≥40% in females were further defined as severe ob...

Objectives: To investigate the associations of obesity with growth and puberty in children.Methods: From November 2017 to December 2019, height, weight, and Tanner stages of 26879 children aged 3-18 years in Fuzhou, China were assessed.Results: The obesity group was significantly taller than the non-obesity group after 4 years-old for both genders, yet there was no significant diff...