IMPE Abstracts

Background: Healthy living, as well as treatment of overweight and obesity, includes a trend towards personalized diets. To better design these diets, predicting an individual’s metabolic response to specific nutrients is necessary and to do so we must understand how nutrients are perceived by metabolic circuits and to identify the signals involved. Moreover, as males and females respond differently to an obesogenic environment, how energy perception dif...

Human growth is regulated by the growth hormone (GH)/insulin-like growth factor (IGF) axis, which also plays an essential role in energy homeostasis. GH regulates hepatic expression of IGF-1 and modulators of IGF bioavailability, including specific IGF-binding proteins (IGFBPs) and the acid-labile subunit (ALS) that bind IGFs to form binary and ternary complexes, respectively, to increase the half-life of IGF in the circulation. When these complexes reach target tissues specif...

The growth hormone (GH)-insulin-like growth factor (IGF-1) axis determines growth during different stages of life. Mutations resulting in deficiency of pregnancy-associated plasma protein-A2 (PAPP-A2), a protease involved in the release of free IGF-1, leads to problems in growth, reduced bone density and body mass and mild glucose intolerance. To better understand the physiological role of PAPP-A2, we analyzed the metabolic status and lipid metabolism in a mouse model of homoz...