IMPE Abstracts

Monogenic diabetes is a group of diabetes subtypes that can be classified as neonatal diabetes and maturity onset diabetes of the young. Here we present 12 confirmed patients for monogenic diabetes at the Hospital Universitario del Valle at Cali, Colombia from 2014 to the present year from our total population of 412 patients with CIE10 diagnosis of diabetes in patients under the age of 18 years of age. Here we documented mutations associated with MODY on the GCK gene for 3 pa...

Introduction: MODY is a heterogeneous group of monogenic disorders that occurs due to β cell dysfunction. The estimated MODY prevalence is around 1–5% of all diabetes mellitus cases, but it varies depending on the population studied. MODY2 is caused by heterozygous inactivating mutations in the glucokinase (GCK) gene loci 7p13. That result in persistent, stable and mild fasting hyperglycemia, glycosylated hemoglobin alterations. Patients with GCK mu...

A 37 wk of gestation newborn male from a mother with Gestational diabetes also IUGR, consanguineous parents, with persistent glucose levels around 425 mg/dl since his second postnatal day of life with Birth weight of 1640 grams (SD -4.4) and Birth length 41 centimeters (SD -4.6). A diagnosis of Neonatal Diabetes was made and initially he was treated with intravenous insulin to later be switched to SC insulin, basal-prandial therapy analogues (Lispro 0.5 IU if glucose >250 m...