IMPE Abstracts

Introduction: Central precocious puberty (CPP), the development of secondary sex characteristics before ages 8 and 9 years in girls and boys, is caused by premature activation of the hypothalamus-pituitary-gonadal (HPG) axis. A gonadotropin-releasing hormone stimulation (GnRH test) is the gold standard diagnostic method to confirm activation of the HPG axis and peak LH levels higher than 5 IU/L are considered a pubertal response. However, the GnRH test is expe...