Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)

impe0096fc5.3 | Fat, Metabolism and Obesity | IMPE2023

Development of Novel Anorexigenic and Glucoregulatory Chimeric Peptides

L. Roth Christian , S. Chichura Kylie , R. Sweet Ian , Elfers Clinton , Berry Dustin , T. Milliken Brandon , P. Doyle Robert

Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery involves changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). Designing dual or triple agonists based on glucagon-like peptide (GLP)-1 with glucagon, and/or glucose-dependent insulinotropic polypeptide (GIP) are promising novel approaches for anti-obesity drugs tackling different weight-regulatory pathways, albeit such developments co...