IMPE Abstracts

Duchenne muscular dystrophy (DMD) is a rare genetic disease characterized by progressive muscular dystrophy. Immobilization, the pathophysiology of the disease and treatment with glucocorticoids predispose to poor bone health, leading to an increased risk of fracture in these patients. Another of the most common associated endocrinological abnormalities is hypogonadotrophic hypogonadism, which can aggravate bone health. Knowledge of the risk factors and the natural history of ...

Introduction: Puberty is a complex biological phenomenon where secondary sexual characteristics develop, complete sexual maturation and adult size is reached. Central precocious puberty (CPP) in girls is defined as the progressive appearance of sexual characteristics before 8 years old, with advanced bone age and acceleration of growth velocity, due to pituitary gonadal axis activation. Multiple studies have shown an increased incidence of CPP and a faster rat...