IMPE Abstracts

The Noonan syndrome (NS) is part of the rasopathies. Rasopathies are autosomal dominant and recessive disorders due to mutations in genes encoding components or regulators of the RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway, which is essential for cell cycle differentiation, growth, and senescence This syndrome presents three cardinal characteristics: distinctive facial features, postnatal short stature, and cardiac abnormalities. NS coexists with mi...