IMPE Abstracts

Introduction: The IHH gene (Indian hedgehog) is predominantly expressed in the developing skeleton. It encodes a protein produced by chondrocytes and involved in the IHH signaling pathway of paracrine cartilage growth factors (1). This protein, together with the PTHrP (parathyroid hormone-related protein) system, coordinates the proliferation and hypertrophy of chondrocytes (1). Inactivation of the IHH in humans causes numerous skeletal chondrodysplasias, incl...