Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)

impe0096fc11.4 | Diabetes and Insulin 1 | IMPE2023

Meal-induced activation of inflammatory pathways in youth with monogenic diabetes revealed by transcriptome analysis

Schwitzgebel Valerie , Stankute Ingrida , Howald Cedric , Blouin Jean-Louis , Verkauskiene Rasa , Xenarios Ioannis

Introduction: Diabetes represents a heterogeneous group of metabolic disorders, and monogenic diabetes is thought to affect 1- 5% of the pediatric diabetes population. Monogenic diabetes, typically presenting without autoimmune antibodies, causes neonatal diabetes, maturity-onset diabetes of the young (MODY), and syndromic diabetes. The study aimed to gain insight into the gene regulation pathways altered in MODY diabetes following a meal.<p class="abstext...