IMPE Abstracts

In this talk I will describe several effects of Growth Hormone (GH) on mammalian growth and aging. Much of the data is derived from two dwarf and one giant strain of mice produced in our laboratory that possess very different degrees of healthy/unhealthy aging. One of the dwarf lines contains a disruption of the GH receptor and binding protein gene (GHR/BP) [PNAS, 94:13215-13220, 1997]. Homozygous GHR/B P"knockout" mice (GHR-/-) show severe postnatal growth ...