IMPE Abstracts

The accelerated growth phase observed during puberty depends on the combined effects of the somatotropic and gonadotropic axes. Our previous studies have demonstrated that relatively low concentrations of estradiol (20 pg/mL) and high concentrations of testosterone (10 ng/mL), potentiate the JAK2/STAT5 signaling pathway induced by GH in the human hepatic cell line (HEPG2). It is not known whether these effects are direct, or are mediated through the suppressors of cytokine sig...