IMPE Abstracts

Background: Somatrogon is a once-weekly treatment for children with pediatric GH deficiency (pGHD). The goal of this study was to simulate IGF-1 and IGF-1 SDS profiles and calculate the ratio and differences of observations to 96-hour values over the dosing interval.Methods: A population PK model was developed using data from a Phase 2 study and a Phase 3 study in children with pGHD. An indirect-response PK/PD model link...