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impe0096fc5.4 | Fat, Metabolism and Obesity | IMPE2023

Hepcidin is associated directly with inflammatory markers and inversely with glucose in Indigenous Argentinean children

Hirschler Valeria , Gonzalez Claudio , Rica Itxaso , Lapertosa Silvia , Urrutia Ines , Martinez Salazar Rosa , Aguayo Anibal , Antonio Castano Luis

Background: Hepcidin is a protein that could be a link between iron and inflammation. Hepcidin sequesters iron, increasing intracellular ferritin, which promotes tissue damage through the cascade-amplified inflammation.Aim: To determine the association between hepcidin levels with inflammatory markers (PCR, ferritin, Lpa, and neutrophils), and glucose levels in indigenous school children living at 3750 m above sea level....

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impe0096fc9.1 | Endocrinology of Sex Differences 2 | IMPE2023

Uncovering the role of the SF-1/NR5A1 p.Gly146Ala variant for the phenotype of DSD patients

Martinez de Lapiscina Idoia , Kouri Chrysanthi , Aurrekoetxea Josu , Sanchez Mirian , Naamneh Rawda , Sommer Grit , Sauter Kay , Camats Nuria , Grau Gema , Rica Itxaso , Rodriguez Amaia , Vela Amaia , Cortazar Alicia , Concepción Alonso M , Bahillo Pilar , Berthod Laura , Esteva Isabel , Castaño Luis , E Flück Christa

Background and Aim: The SF-1/NR5A1 variant c.437G>C/p.Gly146Ala is common among individuals with disorders/differences of sex development (DSD). It has been considered a polymorphism due to its high allele frequency in the control population (23.5%, gnomAD) and its lack of negative effect in cell-based studies. However, its possible role as a disease modifier is still unclear given that oligogenic inheritance has been described in patients with SF1...

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IMPE Abstracts

Hepcidin is associated directly with inflammatory markers and inversely with glucose in Indigenous Argentinean children

Uncovering the role of the SF-1/NR5A1 p.Gly146Ala variant for the phenotype of DSD patients

BiosciAbstracts