IMPE Abstracts

Human growth is regulated by the growth hormone (GH)/insulin-like growth factor (IGF) axis, which also plays an essential role in energy homeostasis. GH regulates hepatic expression of IGF-1 and modulators of IGF bioavailability, including specific IGF-binding proteins (IGFBPs) and the acid-labile subunit (ALS) that bind IGFs to form binary and ternary complexes, respectively, to increase the half-life of IGF in the circulation. When these complexes reach target tissues specif...

The growth hormone (GH)-insulin-like growth factor (IGF-1) axis determines growth during different stages of life. Mutations resulting in deficiency of pregnancy-associated plasma protein-A2 (PAPP-A2), a protease involved in the release of free IGF-1, leads to problems in growth, reduced bone density and body mass and mild glucose intolerance. To better understand the physiological role of PAPP-A2, we analyzed the metabolic status and lipid metabolism in a mouse model of homoz...