IMPE Abstracts

Objectives/Background: Type 1 Diabetes (T1D) manifests as a loss of insulin secretion due to autoimmune destruction of β-cells by self-reactive T effector lymphocytes. Suppression of autoreactive T effectors by regulatory T cells (Tregs) is a key mechanism of peripheral self-tolerance. T1D subjects have documented numerical and functional Tregs impairment. Recent early-stage clinical trials with adoptively transferred ex vivo-expanded autologous Tregs sho...