IMPE Abstracts

Introduction: The National Program for Strengthening Neonatal Screening (Ministry of Health, Argentina) provides diagnostic reagents to 20 provincial NS centers in Argentina. CAH NS requires the use of appropriate cut-off values in order to detect all true positive cases, minimizing the recall of false positive cases, to reduce the negative impact on families due to unnecessary alerts and the need of confirmatory tests. The NS Laboratory of Hospital of Pediatr...

Hematocrit was considered an uncontrollable variable that affects results of biomarkers in whole blood filter paper samples (FPS). NS methodologies are generally adjusted by assuming a standard hematocrit of 55%. Our group has previously presented a method to estimate hematocrit by measuring hemoglobin values in FPS. This correction has the potential to reduce the number of false positives, improve specificity in NS, and decrease the number of recalled patients.<p class="a...