IMPE Abstracts

Background: Hyperandrogenemia resulting in estrogen-mediated accelerated bone maturation and early growth plate fusion largely contributes to short stature in children with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Aromatase inhibitors block androgen conversion to estrogen and have been used off-label in children with short stature to improve adult height. There have been no adequately powered studies supporting the use of aromatas...