Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)

impe0096p38 | Diabetes and Insulin | IMPE2023

Single Nucleotide Polymorphism +276G>T of ADIPOQ gene and the occurrence of Associated Autoimmune Diseases in children and adolescents with Type 1 Diabetes Mellitus

Usatiuc Lia-Oxana , Szabo Csilla-Eniko , Creț Victoria , Sorin Șerban Radu , Victor Pop Ioan

Background: Type 1 diabetes mellitus (T1DM) and autoimmune diseases, such as autoimmune thyroiditis (AT) or coeliac disease (CD) frequently occur together. Adiponectin is the most abundant circulating adipokine that plays a key role as an insulin-sensitizing protein in metabolic diseases. Autoimmune diseases are associated with decreased levels of adiponectin, previous studies suggesting that adiponectin may be related to disease activity and/or severity in su...