IMPE Abstracts

Introduction: Neurogenin-3 (NEUROG3) is a key transcription factor expressed in endocrine progenitor cells and is necessary for the development of endocrine cells in the pancreas and intestine. Its homozygous pathogenic variants cause an autosomal recessive disorder characterized by congenital malabsorptive diarrhea due to paucity of enteroendocrine cells and diabetes which occurs from the neonatal stage to school age.Objectives:...

Introduction: Central precocious puberty (CPP), the development of secondary sex characteristics before ages 8 and 9 years in girls and boys, is caused by premature activation of the hypothalamus-pituitary-gonadal (HPG) axis. A gonadotropin-releasing hormone stimulation (GnRH test) is the gold standard diagnostic method to confirm activation of the HPG axis and peak LH levels higher than 5 IU/L are considered a pubertal response. However, the GnRH test is expe...