Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)

impe0096p55 | Fat, Metabolism and Obesity | IMPE2023

Association of gut microbiota and glucose metabolism in children with disparate degrees of adiposity

Yuan Xin , Chen Ruimin

Objective: To investigate the characteristics of gut microbiota in children with disparate degrees of adiposity, and analyze the association between gut microbiota, glucose metabolism indicators and inflammatory factors.Methods: Clinical data were examined in 89 Chinese children. Children with body fat (BF)% ≥ 30% were diagnosed as obesity, and ≥ 35% in males and ≥40% in females were further defined as severe ob...

impe0096p135 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | IMPE2023

Intervention effect of probiotics on the early onset of puberty induced by soy isoflavones

Yuan Xin , Chen Ruimin

The relationship between soy isoflavones (SI)-induced gut dysbiosis and puberty onset has not been explored, and the protective effect of probiotic are still controversial. This study investigated the action of SI and probiotic on the age of puberty onset in female c57/bl mice. Changes in the gut microbiota and production of short chain fatty acids (SCFAs) metabolism are highlighted to analyze a possible causative relationship to puberty onset. The results demonstrate that SI ...