IMPE Abstracts

Background: Perinatal stress, fetal growth restriction (FGR) or being small for gestational age (SGA) poses a high risk for neonatal hypoglycemia. The exact pathomechanism is unknown. In an animal model, increased levels of catecholamines were found in FGR sheep, causing β-cell adaptation with suppressed intrauterine insulin secretion, subsequently resulting in a hyper-responsive insulin secretion once the adrenergic stimulus subsides, e.g. after birth. W...

Background: Fetal growth restriction (FGR) has been suggested to cause persistent effects long after birth, namely fetal programming (FP). Although FP has drawn attention, a number of questions remain to be answered. One of the major questions is time dependency, i.e., whether the timing when FP occurs would affect the outcome after birth. Indeed, in neonates born small for gestational age (SGA), a consequence of FGR, the potential of catch-up growth which usu...

Background: Congenital hyperinsulinism (CHI) is characterized by often severe hyperinsulinemic hypoglycemia due to pancreatic beta cell hypersecretion of insulin. Treatment delay confers a high risk of neurodevelopmental impairment (NDI).Methods: We performed a single-center retrospective review of medical records of CHI-patients with EEG recordings, with addition of a blinded, quantitative EEG-analysis with age-matched ...

Background: Cardiometabolic (CM) risk is linked to being born small for gestational age (SGA, birthweight <-2SDS). Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ‘omic signature in SGA catch-up predicts pre-hypertension in adolescence (Garner et al JES 2021). Fetal growth restriction (FGR) alone may be linked with greater CM risk. Therefore, we focused on CM risk in children born following pregnancies at high...