Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)
Volume 96 | IMPE2023

IMPE 2023

Buenos Aires, Argentina
04 Mar 2023 - 07 Mar 2023

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11th International Meeting of Pediatric Endocrinology (IMPE 2023). 4 -7 March 2023 - Buenos Aires, Argentina.

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GH and IGFs 1

impe0096fc1.1 | GH and IGFs 1 | IMPE2023

Treatment with recombinant murine Pappa2, GH or IGF-1 modifies hepatic energy metabolism in a mouse model of Pappa2 deficiency

del Mar Fernández-Arjona María , Rubio Leticia , López-Gambero Antonio , Vargas Antonio , Vera-Fernández Carlos , Rivera Patricia , Rodríguez de Fonseca Fernando , A. Chowen Julie , Argente Jesús , Suárez Juan

Human growth is regulated by the growth hormone (GH)/insulin-like growth factor (IGF) axis, which also plays an essential role in energy homeostasis. GH regulates hepatic expression of IGF-1 and modulators of IGF bioavailability, including specific IGF-binding proteins (IGFBPs) and the acid-labile subunit (ALS) that bind IGFs to form binary and ternary complexes, respectively, to increase the half-life of IGF in the circulation. When these complexes reach target tissues specif...

impe0096fc1.2 | GH and IGFs 1 | IMPE2023

Dose-dependent Increase in GH AUC0-12h with LUM-201 in Idiopathic Pediatric GH Deficiency (iPGHD) from the Interim Analysis Data of the OraGrowtH212 Trial

Cassorla Fernando , Román Rossana , L Johnson Michael , Avila Alejandra , Iñiguez German , Baier Ingrid , Said Daniela , Bruchey Aleksandra , Smith Christopher , B Karpf David , C McKew John , O Thorner Michael

LUM-201 (ibutamoren), an agonist of the growth hormone (GH) Secretagogue Receptor 1a (GHSR1a), is an investigational oral GH secretagogue currently in three iPGHD Phase 2 trials. The LUM-201 predictive enrichment marker (PEM) may be used to identify patients previously diagnosed with iPGHD who are likely to respond to LUM-201. PEM positivity is defined as a baseline insulin-like growth factor-1 (IGF-1) level >30 ng/mL and a peak GH of ≥5 ng/mL in response to a single 0.8...

impe0096fc1.3 | GH and IGFs 1 | IMPE2023

Age-Dependent and Sex-Specific Changes of DNA Methylation within Growth Hormone Receptor (GHR), Insulin-Like Growth Factor Type 1 Receptor (IGF1R) and Insulin Receptor (INSR) Gene Promoters in Peripheral Blood Leukocytes from Healthy Prepubertal and Pubertal Children

Zoff Luciana , Garcia Francisco , Florencia Fernandez María , Aschettino Giovanna , Veneruzzo Gabriel , Pepe Carolina , Mattone Celeste , Perez Garrido Natalia , Juanes Matías , Saraco Nora , Guercio Gabriela , Alonso Cristina , Belgorosky Alicia , Sonia Baquedano Maria

Growth is influenced by genetic, nutritional, environmental, and hormonal factors, but it proceeds in a remarkably predictable pattern characterized by a constant growth deceleration between childhood and adolescence, when the pubertal growth spurt occurs. This growth deceleration is coordinated in multiple tissues and organs in order to maintain body proportions. Growth hormone (GH)/ insulin-like growth factor type 1 (IGF1) axis and insulin are crucial stimulators of growth, ...

impe0096fc1.4 | GH and IGFs 1 | IMPE2023

Novel Insulin-Like Growth Factor 1 Gene Mutation: Broadening of The Phenotype and Implications for Insulin Resistance

Martin Ayelen , Giacomozzi Claudio , Celia Fernández Maria , Gutiérrez Mariana , Iascone Maria , Domené Horacio , Dominici Fernando , Bergadá Ignacio , Cangiano Biagio , Persani Luca , Pennisi Patricia

Purpose: Insulin-like Growth Factor (IGF)1 gene mutations are extremely rare causes of pre- and post-natal growth retardation. Phenotype can be heterogenous with varying degrees of neurosensory deafness, cognitive defects, glucose metabolism impairment and short stature. This study describes a 12.6-year-old girl presenting severe short stature and insulin resistance, but with normal hearing and neurological development at the lower limit of normal. Methods: DN...