IMPE2023 ePoster Presentations Fat, Metabolism and Obesity (7 abstracts)
Metabolic Disorders in Medicated Adolescents with Isotretinoin
Juan Pablo Hayes , Karol Talavera , Carolina Rocha , Cesar Chavez , Sandra Chavez , Samantha Salvini , Virginia Asbun , Fernando Limpias & Karem Lanuza
Globalpediatrics, Santa Cruz de la Sierra, Bolivia
Introduction: Acne vulgaris affects up to 87% of adolescents. Isotretinoin is the most effective therapy for moderate to severe acne. As adverse effects of isotretinoin have been reported elevated aminotransferases (ALT and AST), hypertriglyceridemia and hypercholesterolemia. A classic dose isotretinoin (0.5-1 mg/kg/day), approximately 20% of patients develop hypertriglyceridemia and hypercholesterolemia.
Objective: To determine the metabolic disorders in adolescents medicated with isotretinoin. Material and methods: Adolescents with acne medicated with isotretinoin, 0.5 mg/kg/day. Variables: Age, sex and BMI (body mass index) of patients. At the beginning and after three months of therapy with isotretinoin: Serum levels of ALT, AST, fasting glucose, triglycerides and cholesterol. Reference levels: ALT and AST, 8-30 IU/L (male), 6-25 IU/L (female); fasting glucose, 70-100 mg/dL.
Results: Investigated universe: 59 adolescents with acne medicated with isotretinoin. Mean of age: 12.6 years (SD 0.8). Age range: 10-14 years. Sex: 34 (58%) female and 25 (42%) male. At the beginning of treatment: Normal serum levels of ALT, AST, fasting glucose, triglycerides, cholesterol: 38 patients (100%). Control at the 3rd month of treatment: Hypertriglyceridemia in 5 patients (8.5%), hypercholesterolemia in 2 (3.4%), elevated levels of ALT and AST in 4 (6.8%).
Conclusions: Laboratory abnormalities are rare. Hypertriglyceridemia was the most common metabolic disorder in adolescents medicated with isotretinoin; in some patients elevated levels of ALT, AST and hypercholesterolemia were observed.
Recommendations: Periodic monitoring of triglyceride, cholesterol and aminotransferases levels is recommended in patients treated with isotretinoin.
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