IMPE2023 Poster Presentations Thyroid (16 abstracts)
Thyroid nodule cytology and malignancy risk in children and adolescents in a terciary centre.
Consuelo Pino 1 , Andy Contreras 1 , Antonieta Solar 2 , Pablo Zoroquiain 2 , Hernán González 3 , Augusto León 3 , Ignacio Goñi 3 , Francisco Cruz 4 , Lorena Mosso 5 , Nicole Lustig 5 , José M. Dominguez 5 & Francisca Grob 1
1Division of Paediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. 2Department of Pathological Anatomy. School of Medicine, Pontificia Universidad Católica de Chile., Santiago, Chile. 3Department of Oncological Surgery, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. 4Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. 5Department of Endocrinology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Introduction: Thyroid nodules (TN) in childhood are infrequent, however, malignancy is reported in around 25%. Thyroid cancer is the most common endocrine malignancy in this age and has clinical, histopathological and molecular differences compared to adults. Fine needle aspiration biopsy (FNAB) is a sensitive test in the pediatric population to exclude malignancy, however, the implied malignancy risk in each reported category is extrapolated to adult population.
Objective: To assess FNAB performance in children with TN who underwent surgery in a terciary centre.
Patients and Methods: We analised the medical records of patients under the age of 18, who underwent a FNAB and surgical biopsy at a terciary university hospital, between 2006 and 2022. Cytological interpretation was performed by 2 cytopathologists, and reported according the Bethesda System for Reporting Thyroid Cytopathology (BSRTC).
Results: Fifty four subjects aged 14.96 ± 2.3 years (72% women, 92% pubertal) were included. Mean TSH at diagnosis was 2.5 ± 2 uUI/ml. Within cytological categories, malignancy rates were similar to those reported in adults and previously in our cohort: BSRTC III= 33.3%, IV = 36.3%, V= 100%, VI 100%. Among histopathologic diagnosis, 93.5% were papillary cancer with multifocal involvement in 32.5%.
Conclusion: Among this cohort, malignancy rates are comparable to those reported previously in adult population. This finding might reflect a predominantly adolescent population, more similar to adults. Additionally, these findings suggest that a more conservative approach in management is possible in adolescent patients with indeterminate lesions.
Article tools
My recent searches
My recently viewed abstracts
Authors
IMPE Abstracts
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more