IMPE2023 Poster Presentations Fat, Metabolism and Obesity (15 abstracts)
Persistence of Metabolic Healthy phenotype in Metabolically Healthy Obese Indian children and adolescents.
Manojkumar Agrawal 1 , Anurag Bajpai 1 , Chetan Dave 2 , R. Narayanan R 2 , Sayan Benerjee 2 , Rishi Shukla 2 & Vibha Yadav 2
1CDER, Regency Hospital, Kanpur, India. 2CDER, Kanpur, India
Background: Most children and adolescents with obesity have metabolic complications; however, a substantial proportion of these remain metabolically healthy. A paucity of data about the course of children and adolescents with metabolically healthy obesity is unclear due to limited information.
Aim: To determine the course and its predictors of metabolically healthy obesity in obese Indian children and adolescents.
Method: Sixty obese children and adolescents with metabolically healthy obesity (35 boys; age mean 11.7 + 2.8 years) were followed for 2.0 + 1.5 years till 13.8 + 3.4 years. Metabolic profiles (oral glucose tolerance test, lipid profile, ALT, blood pressure) were measured at six and twelve months and then annually.
Results: BMI SDS remained stable over follow-up (2.4 + 0.8 to 2.3 + 0.5, P=0.23), with only five subjects becoming normal or overweight. Sixteen subjects (26%) developed metabolic complications during the study period (hypertension in five, fatty liver in three, pre-diabetes in four, and dyslipidemia in four). Baseline body fat (40.8 + 17.6% as against 45.3 + 13.4%, P=0.71), BMI SDS (2.4 + 0.8 as against 2.3+ 0.5, P=0.819), and rise in BMI SDS (0.14 + 0.46 as against -0.02 + 0.3, P=0.17) did not predict progression of metabolic complication.
Conclusion: Obese children and adolescents with metabolically healthy obesity remain healthy on follow-up despite persistent obesity. The lack of predictive value of BMI SDS, change in BMI SDS, and age for metabolic complications suggests the role of genetic and epigenetic factors in determining these complications.
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