IMPE Abstracts

Introduction: A significant increase in the incidence of precocious puberty secondary to the COVID-19 pandemic has been demonstrated worldwide. This phenomenon appears to be related to lifestyle changes forced by confinement.Objective: To perform a retrospective evaluation of newly diagnosed idiopathic central precocious puberty (ICPP) during and after COVID-19 confinement at the National Institute of Pediatrics (NIP), c...

Background: Pituitary gigantism is a rare endocrine disease characterized by unusually tall stature due to growth hormone (GH) excess as a result of a GH-secreting pituitary tumor or hyperplasia, which occurs before epiphyseal closure. Treatment includes surgery, medical treatment and radiotherapy (RT),Objective: describe the clinical course of 9 patients with pituitary gigantism.Materials ...

Background: The etiological investigation of central precocious puberty (CPP) has improved with more precise clinical approach, neuroimaging, and genetic studies. CPP can be caused by congenital or acquired conditions, with or without central nervous system (CNS) lesions. More recently, genetic and epigenetic disorders have been identified in children with CPP, previously classified as idiopathic.Objective: To update the...

Introduction: Self-limited delayed puberty is defined as the absence of pubertal signs by 13 years in girls and 14 years in boys, but with normal pubertal development starting before 18 years of age. This condition is known for its strong heritability. This study aimed to identify new candidate genes for pubertal delay.Methods: Fifty-six patients with confirmed self-limited delayed puberty after retrospective evaluation ...

Background: Although previous studies suggested that there is a certain level of body fat mass before puberty can be initiated, most studies have focused on girls.Objective: To investigate the relationship between precocious puberty and physical growth in school-aged children in Beijing, China.Methods: 7590 Chinese children (3591 girls and 3999 boys) aged 6–11 years were recr...

Background: There are limited studies of growth and growth velocity (GV) after discontinuation of GnRHa in ICPP girls. Controversy exits about the growth after GnRHa especially regarding age of onset/end of treatment and onset of menses.Objective: To evaluate growth after GnRHa discontinuation up to final height (FH) by growth velocity analysis (GV), time of menarche (TM) and change of standard deviation of height for bo...

Background: Pediatric papillary thyroid cancer (PTC) is traditionally treated with total thyroidectomy and radioactive iodine (RAI). However, growing evidence suggests that not all patients benefit from RAI. Our objective was to describe clinicopathologic features and outcomes of patients with pediatric PTC who did not receive upfront adjuvant RAI therapy.Methods: Using an IRB-approved database at a tertiary referral can...

In the setting of iodine excess, organification of thyroglobulin is blocked, serving as a protective mechanism against hyperthyroidism. This phenomenon, the Wolff-Chaikoff effect, can result in persistent hypothyroidism. Excessive iodine exposure is usually iatrogenic, coming in the form of radiographic dyes, amiodarone, and povidone-iodine antiseptic solution. In March 2022, the US Food and Drug Administration (FDA) released a statement that at-risk children up to age 3 years...

Background: Thyroid function tests are the most performed endocrine test indicated in various disorders. Appropriate assessment is essential for the timely diagnosis and management of these disorders. Lack of access to specialist pediatric endocrine care makes interpretation of thyroid function tests in resource-poor settings. There is a need for developing a point-of-care tool for guidance on thyroid function interpretation.Aim:...

Introduction: Thyroid Hormone Resistance (THR) is an uncommon genetic condition caused by decreased tissue sensitivity to thyroid hormones (THs). The main finding is the presence of elevated THs levels with unsuppressed TSH. In THR clinical signs of hormonal deficiency, sufficiency and excess can coexist.Aim: To report the clinical and biochemical findings in patients withTHR, highlighting common characteristics that cou...