IMPE Abstracts

Introduction: Neonatal hyperthyroidism is a rare condition frequently caused by the transplacental passage of TSH receptor antibodies (TRAb) from mothers affected by Graves’ disease (GD). Hyperthyroidism may occur in 1 to 8% of children born to women with this condition. The effects of maternal hyperthyroidism in the foetal developing brain are known to have deleterious effects. After birth, neuropsychological manifestations of overt hyperthyroidism are ...

Introduction: Central diabetes insipidus (CDI) affects 2 to 15% of children with Langerhans cell histiocytosis due to destruction of the neurohypophysis. Management includes access to free water and desmopressin (dDAVP), a synthetic analog of AVP, which has a longer half-life than vasopressin. dDAVP can be administered orally, intranasally, or parenterally, depending on the clinical setting. Protocols describing continuous infusion of dDAVP have been reported ...

Introduction: Thyroid nodules (TN) in childhood are infrequent, however, malignancy is reported in around 25%. Thyroid cancer is the most common endocrine malignancy in this age and has clinical, histopathological and molecular differences compared to adults. Fine needle aspiration biopsy (FNAB) is a sensitive test in the pediatric population to exclude malignancy, however, the implied malignancy risk in each reported category is extrapolated to adult populati...