Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)

impe0096fc6.3 | Adrenals and HPA Axis 1 | IMPE2023

Disruption of Pediatric Cushing Syndrome Evaluations by Heterophile Antibodies interfering with an Adrenocorticotropic Hormone (ACTH) Assay

Jumani Sanjay , Yanovski Jack , Nieman Lynnette , Cole Justine , Harb Roa , Gun Hasan , Lightbourne Marissa

Contemporary ACTH assays have variable susceptibility to interference by endogenous antibodies, particularly heterophile antibodies, leading potentially to unnecessary investigations1-6. Often, determining the cause of the spurious ACTH results is impossible beyond identifying the presence of interference of heterophile antibodies6. Here we describe two cases of Cushing Syndrome due to Primary Pigmented Nodular Adrenocortical Disease (PPNAD) whose evaluat...