IMPE Abstracts

Objective: to assess the association of different markers of adiposity during childhood with different pubertal milestones (age at: thelarche, pubarche, menarche, and peak height velocity (PHV)).Design: longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort Study.Setting: A population-based study from the low-middle socioeconomic status of the So...

Context: Premature adrenarche in girls is defined biochemically by an increase in adrenal androgen (DHEA and DHEAS) levels above the age-specific reference range before age 8 years. Recently, increased levels of 11-oxyandrogens have also been observed in girls with premature adrenarche. On the other hand, epigenetic control of some genes that code for enzymes that participate in the synthetic pathway to 11-oxyandrogens (e.g., CYP11B1) has been describ...