IMPE Abstracts

Introduction: Central diabetes insipidus (CDI) affects 2 to 15% of children with Langerhans cell histiocytosis due to destruction of the neurohypophysis. Management includes access to free water and desmopressin (dDAVP), a synthetic analog of AVP, which has a longer half-life than vasopressin. dDAVP can be administered orally, intranasally, or parenterally, depending on the clinical setting. Protocols describing continuous infusion of dDAVP have been reported ...

Introduction: Thyroid cancer is the most common endocrine neoplasm in childhood: incidence 1.6/million children <15 years, with a progressive increase over time. They present as mostly benign thyroid nodules, but up to 25% may be malignant. Well-differentiated papillary carcinoma is the most frequent in the general population, but in prepubescents it presents in a more advanced and aggressive way than in the adult population. Poorly differentiated thyroid c...

Introduction: Maternal Graves' disease (GD) is the most common cause of neonatal hyperthyroidism. Which by definition is transient and self-limited. There is also an infrequent cause of non-autoimmune persistent neonatal hyperthyroidism due to activating mutations in the TRH receptor (TSHR), both familial (FNAH) and sporadic (PSNAH), or to Protein G Mutation (Macune Albright Syndrome (GNAS). Neonatal screening for thyroid disease focuses on prevention of ...

Neonatal Diabetes (ND) is a rare genetic disease (1 in 90,000 live births); most cases will be diagnosed before 6 months of age. The third cause by frequency, is mutations of the insulin gene (INS); the majority are heterozygous mutations a&fflig;ecting the structure of preproinsulin; these are transmitted in an autosomal dominant manner.Clinical case: Third Child of non-consanguineous parents, male, controlled pregnancy at high obstetri...

Introduction: Thyroid nodules (TN) in childhood are infrequent, however, malignancy is reported in around 25%. Thyroid cancer is the most common endocrine malignancy in this age and has clinical, histopathological and molecular differences compared to adults. Fine needle aspiration biopsy (FNAB) is a sensitive test in the pediatric population to exclude malignancy, however, the implied malignancy risk in each reported category is extrapolated to adult populati...