IMPE Abstracts

Background: Neonatal hypoglycemia is the most common metabolic condition in neonates. It affects about 15 % of all neonates and about 50 % of neonates born with risk factors, including maternal diabetes, large- or small-for-gestational age, or prematurity. While it is known that hypoglycemia in congenital hyperinsulinism can lead to brain injury, it is still not clear to what extent transitional neonatal hypoglycemia is tolerated during the first days of life ...

Background: Perinatal stress, fetal growth restriction (FGR) or being small for gestational age (SGA) poses a high risk for neonatal hypoglycemia. The exact pathomechanism is unknown. In an animal model, increased levels of catecholamines were found in FGR sheep, causing β-cell adaptation with suppressed intrauterine insulin secretion, subsequently resulting in a hyper-responsive insulin secretion once the adrenergic stimulus subsides, e.g. after birth. W...