IMPE2023 Free Communications Diabetes and Insulin 1 (4 abstracts)
1Instituto Nacional de Pediatría, Mexico City, Mexico. 2Unidad de Investigación en Enfermedades Metabólicas, CMNSXXI, IMSS, Mexico City, Mexico
Objective: Identify the factors association with the serum level of RIAO (real IAPP amyloid oligomers) <3.02 μg/ml at the diagnosis of the DM2 as a predictor of development of chronic complications in children and adolescents.
Type of study: Historical cohort, observational, longitudinal, futurology, comparative,
Materials and methods: The DM2 patients with determinations of RIAO records were reviewed. We recorded factors associated with chronic complications (weight, height, [IMZ], glucose, HbA1c, lipid profile, AST, ALT, creatinine, uric acid, [microalbuminuria]) at the diagnosis and during the monitoring at the INP Diabetes Clinic from 2013 to 2020. We calculate measures of central tendency and dispersion. We analyze the association between the different factors with the RIAO value by calculating the ratio of odds ratio and confidence interval at 95% and by logistic regression analysis its probability of presenting the outcome using the STATA v15.1 program. Evaluated and approved by the INP and IMSS Committees.
Results: We presented 17 patients with DM2 with RIAO of 2.21 μg/ml (1.01 a 6.25). We divided the patients by the RIAO value into two groups: RIAO less than 3.02 μg/ml and RIAO higher than or equal to 3.02 μg/mL. By multi-way analysis we observed that patients in the group with RIAO less than 3.02 μg/ml had a higher BMI, lower HDL cholesterol, higher elevation of liver enzymes and uric acid compared to the group with RIAO > 3.02 μg/ml at diagnosis and persisted during evolution.
Conclusions: The role pf the RIAO as predictor indicator emerge, by showing that is capable of identifying pediatric patients with DM2 at high cardiovascular risk. It opens the possibility that 100% of Mexicans can benefit from a timely diagnosis.