IMPE Abstracts

Background: Healthy living, as well as treatment of overweight and obesity, includes a trend towards personalized diets. To better design these diets, predicting an individual’s metabolic response to specific nutrients is necessary and to do so we must understand how nutrients are perceived by metabolic circuits and to identify the signals involved. Moreover, as males and females respond differently to an obesogenic environment, how energy perception dif...

Background: The assessment of childhood obesity involves the rational use of diagnostic tests in physiological causes while not missing pathologies. We have developed an obesity interpreter, a mobile application that provides individualized guidance regarding the workup of children and adolescents.Aim: To develop and validate a mobile application to evaluate children and adolescents with obesity.<s...

Objective: to assess the association of different markers of adiposity during childhood with different pubertal milestones (age at: thelarche, pubarche, menarche, and peak height velocity (PHV)).Design: longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort Study.Setting: A population-based study from the low-middle socioeconomic status of the So...

Introduction: The melanocortin-4 receptor (MC4R) pathway is an important regulator of energy balance and body weight. Several key genes are associated with the MC4R pathway, including POMC, PCSK1, LEPR, NCOA1, and SH2B1. These genes work in concert within the hypothalamus to regulate leptin signaling and activation of MC4R. However, the molecular mechanisms of these genes and the clinical characteristics of individu...

Background: Sarcopenia is a common disorder among elderly people defined by the loss of skeletal muscle mass accompanied by a physical function disorder. In recent years, it has been reported that the loss of skeletal muscle mass is a poor prognostic factor in pediatric cancer patients as well as adult cancer patients. In the elderly, a decrease in IGF-1 was suggested to be one of the responsible factors in the development of sarcopenia, but there have been no...

Bariatric surgery is becoming a modality of treatment for severe obesity in adolescents. Referral to surgery is governed by certain policies which mandates presence of certain comorbidities. Family history of bariatric surgery might encourage families to seek surgery referral for adolescents with severe obesity as anti-obesity medications are not widely available and lifestyle modifications are challenging. The study design is observational retrospective inclusive of patients ...

Background: Domestic and international epidemiological studies have reported that childhood obesity and serum lipids were associated with lifestyle-related diseases in adulthood. There are few long-term epidemiological studies on the relationship between serum lipids and obese in Japanese children.Purpose: Based on the data Oita City schoolchildren lifestyle-related disease screening program (height, weight, serum total ...

Objectives: Vitamin D deficiency is prevalent in pediatric population. Since low compliance may inhibit appropriate vitamin D supplementation in daily dosing regimen, intermittent high dose administration may be considered. We aimed to evaluate the efficacy and safety of monthly administration of oral cholecalciferol compared with daily dosing regimen in adolescents with vitamin D deficiency.Methods: This retrospective s...

Background: Most children and adolescents with obesity have metabolic complications; however, a substantial proportion of these remain metabolically healthy. A paucity of data about the course of children and adolescents with metabolically healthy obesity is unclear due to limited information.Aim: To determine the course and its predictors of metabolically healthy obesity in obese Indian children and adolescents.<p c...

Monogenic obesity is a rare, severe condition, associated with early-onset weight gain. In the last years, due to advances in genetic technique and sequencing technology, an increasing number of variants causing monogenic obesity has been described, mostly genes encoding components of leptin-melanocortin pathways. The accessory protein MRAP2 (Melanocortin Receptor Accessory Protein 2) acts in body weight regulation and its inactivation is associated with early-onset severe obe...