IMPE Abstracts

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Cumulative lifetime incidence and prevalence of endocrine abnormalities after treatment of childhood cancer increases, particularly after high-risk regimes. Both men and women experience gonadal toxicity with reduced fertility. Effects of chemotherapy and /or radiation exposure will focus on adverse effects of treatment on gonadal function, assessment of gonadal status, options for fertility preservation (FP) and risks associated with gonadal dysfunction and its treatment. For...

Skeletal dysplasia (SD) and metabolic bone diseases (MBD) are congenital diseases which result in abnormalities in bone morphometry and mineral metabolism. Advances in molecular genetics research have revealed many gene variants that cause SD and MBD. In 2019, nosology and classification of genetic skeletal disorders was revised in which 437 different genes have been found in 425 (92%) of these disorders 1), and new genetic etiologies are continually being discovere...

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Transition is an opportunity for reassessment of pituitary defects of childhood-onset and the need for lifelong replacement therapies. However, although the existing guidelines have described how to re-evaluate GHD during transition, there is no clear plan in many countries about the delivery of transitional care from pediatric to adult services. In particular, GH plays a crucial role not only for growth, but also for the acquisition of bone mass and muscle strength. Thus, con...