Scientific Programme & Abstracts from the International Meeting in Pediatric Endocrinology (IMPE)

impe0096fc2.4 | Fetal and Neonatal Endocrinology | IMPE2023

The Arginine-nitric-oxide Pathway Links Suboptimal Fetal Growth to Higher Childhood Systolic Blood Pressure in the Manchester BabyGRO Study

Perchard Reena , Garner Terence , Higgins Lucy , Murray Philip , Stevens Adam , Johnstone Edward , Clayton Peter

Background: Cardiometabolic (CM) risk is linked to being born small for gestational age (SGA, birthweight <-2SDS). Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ‘omic signature in SGA catch-up predicts pre-hypertension in adolescence (Garner et al JES 2021). Fetal growth restriction (FGR) alone may be linked with greater CM risk. Therefore, we focused on CM risk in children born following pregnancies at high...