IMPE Abstracts

Introduction: Minipuberty describes the transient sex-specific activation of the hypothalamic-pituitary-gonadal (HPG) axis during the first 2 years in girls. Data in preterm are scarce, but It seems that the HPG axis activation is more intense and prolonged compared with full-term infants, resulting in higher sex steroid concentrations, sometimes with extreme pubertal characteristics.Clinical case: A female infant presen...

Objective: to assess the association of different markers of adiposity during childhood with different pubertal milestones (age at: thelarche, pubarche, menarche, and peak height velocity (PHV)).Design: longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort Study.Setting: A population-based study from the low-middle socioeconomic status of the So...

Perceived diabetes stigma (PDS) has been associated with worse clinical and psychosocial outcomes in adults. Our objective was to examine the associations between PDS, glycemic control, diabetes complications, psychosocial variables, and substance use in adolescents and young adults (AYAs) with type 1 diabetes (T1D) and type 2 diabetes (T2D) in the SEARCH for Diabetes in Youth study, 2016-2019. We hypothesized that greater PDS was associated with worse glycemic control, greate...

Introduction: Paragangliomas (PGLs) are uncommon neuroendocrine tumors. These tumors can originate from either the sympathetic or parasympathetic paraganglia. Cardiac PGLs (CPGLs) are extremely rare, as thoracic localization represents less than 2% of PGLs. There are few reported cases in pediatric age. The most frequent cause of inherited phaeochromocytomas/paragangliomas are germline pathogenic variants in Succinate Dehydrogenase Subunit B, C and D genes (SD...

Objective: The growth plate is the metabolically highly active cartilage portion of the bone where linear growth takes place. Chondrocytes in this region are affected by many hormones and local factors in the process of proliferation, maturation, hypertrophy, extracellular vesicle release and cell death. Melatonin, one of these factors, affects blastic activity, proliferation and mineralization in a circadian rhythm through its receptors in cartilage. In the g...

Introduction: Insulin sensitivity is a marker of cardiovascular health. Young women in reproductive age with type 1 diabetes (T1D) have an increased risk of cardiovascular disease. The metabolic effects of combined oral hormonal contraception (OC) and progestin implant (implant) on insulin sensitivity in young women with T1D are unknown.Objective: To determine the effect on insulin sensitivity in young women with T1D of ...

Background: Healthy living, as well as treatment of overweight and obesity, includes a trend towards personalized diets. To better design these diets, predicting an individual’s metabolic response to specific nutrients is necessary and to do so we must understand how nutrients are perceived by metabolic circuits and to identify the signals involved. Moreover, as males and females respond differently to an obesogenic environment, how energy perception dif...

Bardet-Biedl syndrome (BBS) is a rare disease associated with signaling defects in the melanocortin-4 receptor (MC4R) pathway that lead to hyperphagia, severe obesity, and, consequently, reduced quality of life (QOL). We investigated the impact of setmelanotide, an MC4R agonist, on weight, body composition, hunger, and QOL in a Phase 3 trial of patients with BBS to characterize clinically meaningful and patient-relevant benefit. Patients aged ≥6 years with BBS and obesity w...

Objective: Identify the factors association with the serum level of RIAO (real IAPP amyloid oligomers) <3.02 μg/ml at the diagnosis of the DM2 as a predictor of development of chronic complications in children and adolescents.Type of study: Historical cohort, observational, longitudinal, futurology, comparative,Materials and methods: The DM2 patients with determinations of RI...

Nuclear receptor subfamily 5 group A member 1 (NR5A1), is a member of the nuclear receptor family. It plays a crucial role in transcriptional regulation of genes involved in steroidogenesis, gonadal development and reproduction. NR5A1 mutations represent one of the most frequent defects associated with 46,XY gonadal dysgenesis, associated with a wide phenotypic spectrum of DSD. Some patients with mutations in the NR5A1 may have normal testosterone le...